Total w3 | Healthmatters.io (2025)

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been linked to healthy aging throughout our lifespan - from fetal development to prevention of Alzheimer’s disease. Omega-3 fatty acids are anti-inflammatory and used in cell membrane production, function, and overall gene expression. Most standard American diets are deficient in common n-3 food sources such as flax, oily fish, nuts, and green leafy vegetables. Deficiencies in n-3 have been correlated with many clinical conditions such as neurodevelopmental and behavioral disorders, cardiovascular disease, cognitive decline, mood disorders, skin abnormalities, visual changes, and cancer.

References:

- Lee JM, Lee H, Kang S, Park WJ. Fatty Acid Desaturases, Polyunsaturated Fatty Acid Regulation, and Biotechnological Advances. Nutrients. 2016;8(1).

- Swanson D, Block R, Mousa SA. Omega-3 Fatty Acids EPA and DHA: Health Benefits Throughout Life. Advances in Nutrition. 2012;3(1):1-7.

- Richardson AJ. Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. International review of psychiatry. 2006;18(2):155-172.

- Kris-Etherton PM, Harris WS, Appel LJ. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. circulation. 2002;106(21):2747-2757.

- SanGiovanni JP, Chew EY. The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. Progress in retinal and eye research. 2005;24(1):87- 138.

- McCusker MM, Grant-Kels JM. Healing fats of the skin: the structural and immunologic roles of the ω-6 and ω-3 fatty acids. Clinics in dermatology. 2010;28(4):440-451.

- Riediger ND, Othman RA, Suh M, Moghadasian MH. A systemic review of the roles of n-3 fatty acids in health and disease. J Am Diet Assoc. 2009;109(4):668-679.

- Borow KM, Nelson JR, Mason RP. Biologic plausibility, cellular effects, and molecular mechanisms of eicosapentaenoic acid (EPA) in atherosclerosis. Atherosclerosis. 2015;242(1):357-366.

- Chang JP, Su KP, Mondelli V, Pariante CM. Omega-3 Polyunsaturated Fatty Acids in Youths with Attention Deficit Hyperactivity Disorder: a Systematic Review and Meta-Analysis of Clinical Trials and Biological Studies. Neuropsychopharmacology. 2018;43(3):534-545.

- Cormier H, Rudkowska I, Lemieux S, Couture P, Julien P, Vohl M-C. Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: results from a pre-post fish oil supplementation. Genes & nutrition. 2014;9(6):437.

- Das UN. Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review. Journal of advanced research. 2018;11:43-55.

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